Ganfort PF Drug Interactions

No interaction studies have been performed with Ganfort PF.
Beta-adrenergic blocking agents: Patients who are receiving a systemic (e.g., oral or intravenous) beta-adrenergic blocking agent and Ganfort PF should be observed for potential additive effects of beta-blockade, both systemic and on intraocular pressure.
Anti-hypertensives/cardiac glycosides: There is a potential for additive effects resulting in hypotension, and/or marked bradycardia when beta-blocker eye drops are administered concomitantly with oral calcium channel blockers, anti-arrhythmics (including amiodarone), digitalis glycosides, parasympathomimetics, guanethidine and other anti-hypertensives.
Mydriatic agents: Although timolol has little or no effect on the size of the pupil, mydriasis has occasionally been reported when timolol has been used with mydriatic agents such as adrenaline.
CYP2D6 inhibitors: Potentiated systemic beta blockade (e.g., decreased heart rate, depression) has been reported during combined treatment with CYP2D6 inhibitors [e.g., quinidine, selective serotonin reuptake inhibitors (SSRIs)] and timolol.